We found that the proportion of patients receiving chemotherapy decreased with age 80.0%, 70.4%, 50.6%, and 30.2% of patients aged 70–74, 75–79, 80–84, and ≥ 85 years, respectively, received chemotherapy. ![]() The first-line chemotherapy regimens among 9,737 patients who were diagnosed with advanced lung cancer between January and December 2013, were identified and compared based on age. Data from the survey database of Diagnostic Procedure Combination and hospital-based cancer registries of designated cancer centers nationwide were used. This study aimed to examine the prescribing patterns of first-line chemotherapy according to age in the real-world practice. In clinical practice, physicians are required to decide the treatment based on a lack of enough evidence. In Japan, single agent chemotherapy was recommended for advanced non-small cell lung cancer (NSCLC) for those, who were aged ≥75 years, while the Western guidelines did not recommend a specific regimen. Incidence of grade 3-5 adverse events was similar in the pembrolizumab-combination (71.9%) and placebo-combination (66.8%) groups.įirst-line pembrolizumab plus pemetrexed-platinum continued to demonstrate substantially improved OS and PFS in metastatic nonsquamous NSCLC, regardless of PD-L1 expression or liver/brain metastases, with manageable safety and tolerability.Aging of the population has led to an increase in the prevalence of cancer among older adults. OS and PFS benefits with pembrolizumab were observed regardless of PD-L1 expression or presence of liver/brain metastases. Median (95% CI) time from randomization to objective tumor progression on next-line treatment or death from any cause, whichever occurred first (progression-free-survival-2 PFS-2) was 17.0 (15.1 to 19.4) months and 9.0 (7.6 to 10.4) months, respectively (HR, 0.49 95% CI, 0.40 to 0.59). No alpha was assigned to this updated analysis.Īs of Septem(median follow-up, 23.1 months), the updated median (95% CI) OS was 22.0 (19.5 to 25.2) months in the pembrolizumab-combination group versus 10.7 (8.7 to 13.6) months in the placebo-combination group (hazard ratio, 0.56 95% CI, 0.45 to 0.70]). Response was assessed per RECIST (version 1.1) by central review. Eligible patients with disease progression in the placebo-combination group could cross over to pembrolizumab monotherapy. Patients were randomly assigned (2:1) to receive pemetrexed and platinum plus pembrolizumab (n = 410) or placebo (n = 206) every 3 weeks for 4 cycles, then pemetrexed maintenance plus pembrolizumab or placebo for up to a total of 35 cycles. We report an updated analysis from KEYNOTE-189 (: NCT02578680). In KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo plus pemetrexed-platinum in patients with metastatic nonsquamous non‒small-cell lung cancer (NSCLC), irrespective of tumor programmed death-ligand 1 (PD-L1) expression. 24 Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy.21 Kansai Medical University Hospital, Osaka, Japan.20 Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.19 Hospital Universitario Quirónsalud Madrid, Madrid, Spain.18 Department of Oncology, University of Turin, Azienda Ospedaliero-Universitaria San Luigi, Orbassano, Italy.17 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.16 LungenClinic, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.15 Epworth Healthcare, Richmond, Victoria, Australia.14 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.13 Soroka Medical Center, Ben-Gurion University, Beer Sheva, Israel.11 Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.9 Southern Medical Day Care Centre, Wollongong, New South Wales, Australia. ![]() ![]()
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![]() Longer Warranty: A two-year warranty, as opposed to a one-year warranty for adult Kindles.Other than the cover, two things distinguish these Kindle models from regular adult Kindles: Both models have some form of internal light for reading in the dark and support Bluetooth audio for listening to Audible audiobooks. The chief difference between the two models: the Paperwhite has a higher-resolution screen that’s easier on the eyes and is waterproof. Most models of the Kindle Kids are sold out, and I suspect Amazon may be phasing out the base product to replace it with the more-expensive Kindle Paperwhite Kids, which includes more gender-neutral covers like black, “emerald forest,” and “robot dreams.” (I don’t recommend the Kindle Paperwhite Kids either, as you’ll see-my issues are not with the hardware.) The covers come in blue, pink, “rainbow birds,” and “space station,” which is either good or bad depending on how traditional your views of gender roles are. There’s nothing special hardware-wise about the Kindle Kids: it’s just a standard Kindle bundled with a magnetic cover that puts the Kindle to sleep when closed. Do not buy this product for your children or grandchildren. Getting a Kindle Kids was a huge mistake. Plus, as a parent, I was excited to give him an electronic device that doesn’t have Minecraft, YouTube, and other time-wasting frivolities. Harris has recently started to enjoy reading, and I thought he’d appreciate a Kindle of his own rather than having to borrow his mother’s iPad. That’s why I thought a Kindle Kids ebook reader would make a great gift for my oldest son’s ninth birthday. In fact, it has gotten better with age: PDF support has improved greatly, there’s the great “page flip” feature (see “ Amazon Introduces Page Flip for Kindle,” 28 June 2016), and Amazon is even rolling out EPUB support. It’s longer-lived than many electronics (I’m still using one I bought when I started at TidBITS in 2013), the battery lasts forever, and I can sideload whatever ebooks I want over email or USB. #1663: Exploring the Apple Vision Pro, 12 more OS features coming in 2023, new Apple service features, Apollo shuts downĪvoid the Tempting but Flawed Kindle Kids Ebook ReaderĪmazon’s Kindle Paperwhite might be my favorite non-Apple gadget.#1664: Real system requirements for OS 2023, beware Siri creating alarms instead of timers.#1665: Important OS security updates, abusive Web notifications, solve myopia with an iPhone, Self Service Repair. ![]() #1666: Air quality websites and apps, The Password Game.#1667: OS Rapid Security Responses, 1Password and 2FA, using Siri to request music. It’s also delicious served with pita bread and tzatziki sauce. Sprinkle the lamb chops with kosher salt and pepper and add to the marinade. Lamb chops are great served with a variety of side dishes but I love serving it with a variety of salads or potatoes. Directions Mix together the oregano, garlic, lemon zest from 1 lemon, lemon juice and 1/4 cup olive oil. Rest and serve: Remove the lamb from the heat and allow to rest for 5 minutes then serve with lemon.If you prefer them to medium-rare, cook them for 3-5 minutes per side but allow the fat to render and crisp for the best end result. I prefer my lamb chops to be medium which is why I cook them for approximately 12-15 minutes. 1/4 cup balsamic vinegar 1 tablespoon chopped fresh rosemary or dried rosemary 1/4 teaspoon garlic powder 1/4 teaspoon pepper Salt 4 lamb loin chops (1. Stand the lamb chops on their fat caps and allow to cook for another 4-5 minutes until crisp, golden and tender. Add the lamb chops and allow to cook for 5-6 minutes per side, depending on thickness. Grill: Preheat a grill (I like to cook lamb chops over medium-high heat), grill pan or cast-iron skillet over medium-high heat. ![]() Remove the chops from the refrigerator and bring up to room temperature before grilling. For marinade, combine lemon juice, oil, garlic, 3 tablespoons of the mint, and the pepper. Place the lamb in a large bowl or a suitable airtight container for marinating then pour over the marinade and cover and allow to marinade for at least 30 minutes but ideally up to 4 hours in the fridge. When chips begin to smoke, season lamb with salt and pepper and place on grill.
![]() To cover the potential range of different installs armoured cable is also available in a range of different size cores that include 1.5mm, 2.5mm, 4mm, 6mm, 10mm, 16mm and more specialist 25mm.Īs to how armoured cable is actually made up there are essentially 5 different levels that includes the conductor or conductors ate the core, the insulation around each conductor, a layer of bedding around the conductors, the armouring layer around the bedding and then finally a protective PVC outer sheath.Ĭross section of armoured cable showing all the different cores 5-core = 1 brown, 1 grey, 1 blue and 1 yellow/green. ![]() 4-core = 1 brown, 1 black, 1 grey and 1 blue.3-core = 2 different types: 1 brown, 1 blue and 1 yellow/green (earth) or: 1 black, 1 grey and 1 brown.When it comes to the core wire colours these are generally as follows (depending on the number of cores): There are however others but these are generally reserved for more specialist industrial applications. In terms of the conductors (the charge-carrying copper wire), domestic armoured cable comes in a range of different cores including 1 core, 2 core, 3 core and 4 core and 5 core to suit different install situations. ![]() It can be used both on the interior or the property and the exterior and it can either be clipped to a solid secure surface such as a wall or it can be buried in the ground and hidden away. The cable itself can be used in a variety of different ways. SWA or steel armoured electrical cable (British standard BS5467)is a type of electrical supply cable that as you may have guessed has it’s own in-built armoured sheath that protects the electrical charge-carrying conductor cable at the core. Note: Installing SWA armoured cable is Part P notifiable work and not something that can be done on a DIY basis and should only be done by a qualified electrician with the necessary experience to fully test the install once complete! What is Armoured Cable and How is it Made up? ![]() In this guide we will take a look at SWA cable and how it’s used. To these ends the regulations state that in these situations special cable known as “armoured” or “SWA (steel wire armoured)” cable must be used as it’s both resistant to the elements and it’s protective steel casing ensures resistance to any impact damage. We are shaping the future trends of electrification, differentiating through technological and digital innovation while delivering an outstanding experience through operational excellence for our customers across utilities, industry, buildings, infrastructure and mobility.When running any electrical cables externally any cable that’s used has to be both safe for use outside and able to resist the elements and also needs to be able to resist any potential damage, especially if it is buried underground. Our 50,000+ employees are dedicated to transforming how people live, connect and work by delivering safe, smart and sustainable electrification solutions. ABB’s Electrification Business Area is a global leader in electrical products and solutions, operating in more than 100 countries, with over 200 manufacturing sites. Building on more than 130 years of excellence, ABB’s ~105,000 employees are committed to driving innovations that accelerate industrial automation. The company’s solutions connect engineering know-how and software to optimize how things are manufactured, moved, powered and operated. ABB (ABBN: SIX Swiss Ex) is a technology leader in electrification and automation, enabling a more sustainable and resource-efficient future. ![]() Whether you’re saving up for retirement or want to build an emergency fund, having an extra form of income can help you siphon more money into areas you might not have been able to with only one source of income. It can help you establish financial security.Let’s take a look at a few of the potential advantages of bringing in passive income: Many financial experts recommend individuals give passive income a try because it offers a variety of benefits that can boost your personal finance goals. Like any financial decision, you’ll have to consider how opening a passive income stream will impact your financial situation and personal life. For the purpose of this article, we’ll count portfolio income as a type of passive income. Portfolio income is income that’s made from dividends, interest, capital gains, and stock investments.Active income is generally your salary or hourly wage. Active income is essentially the opposite of passive income because it requires an effort to keep and maintain it.So, now that you know what constitutes passive income, let’s talk about what makes passive income different from the other two types of income (active and portfolio). For example, interest income is treated like ordinary income when it comes to taxes, while dividends and capital gains have their own tax category. However, depending on the passive activity, you’ll notice that some are taxed at higher rates than others. Like most other types of income, passive income is taxable. Many people who partake in passive income avenues use it as a secondary source of income while still maintaining their primary income, like their salary or hourly wage. Income from a rental property, investments on the stock market, and participating in affiliate marketing are all examples of passive income opportunities. Passive income is a source of income that requires minimal effort to achieve. ![]()
![]() ![]() On the other hand, a low inventory turnover ratio means your products aren't selling or you're carrying too much inventory at one time, which can be expensive. Meanwhile, owning your warehouse means freeing up space for faster-moving products that increase your bottom line. If you rent your storage space from another company, you can decrease how much you spend monthly on inventory that hasn't moved. Most companies should strive for a high turnover ratio since it reduces the costs associated with storage. Your inventory turnover ratio tells you how many sales you generate from the products in your warehouse, giving you a baseline number to help you determine new ways to improve your ratio and increase online sales. In addition, it may also mean you're not effectively marketing products, so your customers don't know you have inventory in stock to purchase. Most importantly, your inventory turnover ratio can help you make better business decisions in terms of pricing, manufacturing, marketing, and warehouse management.įor example, if your inventory isn't turning over and people aren't buying your products, it could indicate that your prices are too high or too low, depending on current market conditions. Knowing your inventory ratio can improve your business in several ways. How can inventory turnover ratio help your company? The inventory ratio will explain how many times you sold and replenished inventory to help you understand mistakes made during the management process, changes in consumer buying habits, and more. Inventory management is crucial because mistakes can affect your inventory turnover ratio, including a slower-than-usual supply chain, overstocking, and changes in customer demand. Ultimately, it's the number of times you replace your inventory compared to the cost of the stock over a period of time. What is inventory turnover? Inventory turnover is a value that shows how often your inventory turns over or moves, measuring how fast companies sell products. iWork presents a new opportunity to bring in new customers and take advantage of that halo effect, and it’ll be interesting to see just how far Apple goes in terms of offering iCloud services independent of hardware. The fact is that iWork for Apple is something to dangle at potential customers, which gives it an advantage over Microsoft, which still has to derive revenue somehow from Office, despite a gradual decrease in cost to access for Redmond’s productivity software.Īpple generally enjoys a halo effect resulting from people using their lower cost entry-level devices and investing in other parts of their product line. By Fionna Agomuoh NovemListen to article Microsoft has now made available a feature for Windows 11 that will make it easy to connect your iCloud to your Photos app on your PC. Today, it completes the transition from revenue source to value-add service for iWork, with a web version that serves as a taste of Apple’s ecosystem offerings even for the uninitiated. ![]() IWork used to be a paid productivity suite that Apple sold first via boxed copies then via the Mac App Store. The web-based versions of Apple’s iWork suite are surprisingly complete, and also manage to keep getting better, thanks to updates that have brought features like interactive charts and a much better user interface to the platform since its introduction back in 2013. So far, that’s only available via the public iCloud Beta, but presumably if all goes well with the test that will roll out to the standard version of iCloud after that. iWork for iCloud is a suite of online office applications (consisting of Pages, Keynote, and Numbers) that sync with the Mac and iOS versions of the programs. The company made its iWork for iCloud apps available to anyone, regardless of whether or not they have any Apple hardware, so long as they have or sign up for an Apple ID. Apple has taken another step toward turning iWork into a service anyone can take advantage of, similar to Google’s web-based productivity suite. Koki Riley covers LSU sports for The Daily Advertiser. "We will not start the game unless we have a window to play the game," Johnson said. ![]() With a trip to the College World Series on the line, Johnson clearly understands the stakes at hand. LSU can't afford to have any of its starters – especially Paul Skenes – have their outings cut short due to rain, even if the odds, as of Friday, of there being showers or lightning before Game 1 appear to be relatively low. And for now, there are no thunder or lightning storms on The Weather Channel's forecast. The weather forecast in Baton Rouge calls for a 32% chance of rain on Saturday and an 18% chance of rain on Sunday, according to The Weather Channel as of Friday. SUPER REGIONAL INFO: LSU baseball in NCAA Tournament super regional vs. LSU BASEBALL STRATEGY: LSU baseball: Jay Johnson, Gavin Dugas explain new defensive infield strategy WHAT LSU CAN LEARN FROM LAST SERIES: 3 lessons LSU baseball can learn from last series vs. That meant Thatcher Hurd had to throw more innings on Sunday, weakening LSU's pitching depth for Monday's game. tenDayWeather - Baton Rouge, LA asOfTime Excessive Heat Warning alertCountText There is a possible risk of severe weather tonight. ![]() The Tigers got nine innings outs of ace starter Paul Skenes on Friday, but Sunday starter Ty Floyd only threw three innings before the weather delay forced Johnson to take him out of the game. ![]() More than anything else, LSU's pitching at last week's regional was greatly affected by the weather delays. The weather forecast in Baton Rouge calls for a 32 chance of rain on Saturday and an 18 chance of rain on Sunday, according to The Weather Channel as of Friday. The heaviest storms were expected to hit the Acadiana area around midday, Baton Rouge at mid-afternoon and New Orleans around the evening rush hour, though individual rotating storms that could. View Gallery: LSU Baseball vs Oregon State NCAA Tournament Regional final photos ![]() ![]() Box Office workers are professional and polite- thankfully. Note: Women bring a sweater or a pashmina for protection from the air conditioning's arctic chill. Air conditioner is working at full blast that will chill you within half hour from the blazing hot sun and humidity. Lobby area is very large that can accommodate patrons eagerly waiting to be seated for early arrival before the curtain goes up. Facilities are upgraded to 2017 era and the stalls are not small with auto flush and for women tampons are free (no feminine napkins) and readily available by the sink. This is my first time to patronize Hudson Theatre, thus I have no previous knowledge of how it formerly appeared. Hudson Theatre is small theatre with a seating capacity under 1000. Beautifully restored from decades of being in a dilapidated state. Seats are NOT stadium style but are slanted and new cosmetic seats of dark mahogany with extreme plenty of leg room, nevertheless this theatre is newly renovated and re-opened Februdesignated as a landmark in 1987 by the City of New York. I was seated Orchestra left, Band A in full view of the stage. Hudson Theatre is well equipped with excellent sound system of good quality acoustics and good lighting (use of strobe lights), sound effects (smoke machines, haunting melodies, snow globes) and eerie voice overs. I'm going to the theatre!! I love performance arts. ![]() The Murray panel is a classic- that’s why many own a breaker box of its kind. ![]() They have provided user-friendly products that were easy to install, such as switches, disconnects, circuit breakers, and panel boards. Murray has been a trusted brand since 1899 that delivered high-quality performance when it comes to electrical solutions. But for others, always check if they’re within the UL listing, or better yet, purchase Murray’s legal breaker substitute, Siemens. ![]() The three products, as mentioned earlier, can replace Murray. Not all breakers that fit in your panel are legitimate and trusted. They are physically interchangeable with Murray and other brands but remember to check your local code to see if it’s legal to install. Lastly, Cutler-Hammer Circuit Breakers are known for their capability to control current for a long time. Square Ds are indeed very safe electrical components. Plus, an indication flag feature lets you identify a breaker trip. It’s a brand that I trust for its sturdy design, easy installation, and reliable function. This one hits close to home due to the same mechanics as its Murray counterpart. These breakers are suitable for controlling excess current, though contractors only use this type of breaker for low voltage use (not exceeding 450 Volts). Their safety mechanism operates in arc-extinguishing mediums at specific atmospheric pressures. However, remember to check your local code before installment.įirst is the Air Circuit Breakers, which are quite different from their Murray equivalent. There are three breaker brands I can recommend that will work. The answer is yes Murray load centers have compatible products other than Siemens, although they’re not cross-listed with Murray panels. Are There Other Murray Compatible Brands? For other Murray brand load centers made before that specific year, kindly check the wiring diagram placed inside your panel door for the approved breaker types made explicitly for that panel. Note that only Murray products from 2002 onwards were cross-listed with Siemens. For a Murray circuit breakers cross reference, here is a table guide from Siemens. The panels include Rock Solid Load Centers, Murray Meter Combo Load Centers, and EQ Small Circuit Load Centers. These CBs have UL listing for usage with the aforementioned Murray panels. Their substitution letter states that Murray panel products made after January 2002 are available for use with Siemens CBs. Since Murray is a sub-brand of Siemens, most of their components are very similar. So, now, what product manufacturer do you think will do the job? Of course, it’s the leading brand, Siemens. There are similarities between brands that let you interchange the breaker safely without worrying about an arc fault in your electrical main. You can find numerous breakers in the market that possess Murray circuit breaker compatibility. The Best CB Brand for Your Electrical Main
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